Virginia vs. Wake Forest odds, line: 2021 college football picks, predictions from model on 72-58 run

The Cavaliers are 3.5-point favorites in the latest Wake Forest vs. Virginia odds from Caesars Sportsbook.

The SportsLine Projection Model simulates every FBS college football game 10,000 times.

Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread.

While Virginia only lost one home game during that span, Wake Forest has won by an average of more than 10 points since 2008.

Armstrong is second among all FBS quarterbacks in passing yards (1,298) and helped Virginia secure a lead over No.

Virginia's record at Scott Stadium could make it difficult for Wake Forest to stay close.

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