The Magpies are winless in their last five at St. James’ Park and lost to Saints 2-0 in the reverse fixture on Nov. 6.
Southampton is beset by injuries, though Danny Ings and James Ward-Prowse are healthy and those two are a big part of everything the visitors do well.
Team news Center backs Jamaal Lascelles and Federico Fernandez are out for Newcastle, whose injury list has finally slimmed down a bit.
Alexandre Jankewitz is suspended after his early red card in the 9-0 loss to Man United but Jan Bednarek had his suspension overturned on appeal.
Stuart Armstrong, Ibrahima Diallo, Theo Walcott and Kyle Walker-Peters are out through injury, but Oriol Romeu and Jannik Vestergaard return.
Newcastle is a feast or famine club that’s taken six points off Everton but lost to Sheffield United.
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