Cincinnati vs. Houston odds, line: 2021 college basketball picks, Feb. 21 predictions from proven model

The sixth-ranked Houston Cougars will try to bounce back from a tough loss when they host the Cincinnati Bearcats on Sunday in an American Athletic Conference matchup.

The Cougars (17-3, 11-3) dropped a 68-63 decision to unranked Wichita State on Thursday, falling a game behind the Shockers atop the AAC standings.

The Cougars are a 13-point favorite in the latest Cincinnati vs. Houston odds from William Hill Sportsbook, and the over-under for total points scored is 135.5.

Over the past four-plus years, the proprietary computer model has generated an impressive profit of over $2,200 for $100 players on its top-rated college basketball picks against the spread.

The Cougars run a guard-heavy lineup led by Quentin Grimes , who scores 16.7 points and pulls down 6.3 rebounds per game.

The Bearcats have strong leadership in guards Keith Williams , the leading scorer at 14.1 points per game, and David DeJulius, who averages a team-high 4.7 assists.

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